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Among the challenges is to manufacture the channels, which are about 10 feet long, in such a way so that they will not easily shatter or deform as they are heated, which could block the functioning of the control rods.
Another parameter that could contribute to the lack of toxicity is the capacity of an inhibitor to block the functioning of surface nucleolin without affecting nuclear nucleolin, which controls many aspects of gene expression [1], [3].
The finding was, moreover, traced to the ability of high levels of progesterone (characteristic of diestrus) to block the functioning of vomeronasal neurons that respond to male urinary proteins, while not affecting those that respond to a predator odor [ 146].
In contrast, with the AS-associated catalytically inactive mutants that we have analyzed, which have a greatly increased capacity to associate with S5a, this might be expected to directly block the functioning of the S5a subunit.
Another parameter that could contribute to the lack of toxicity is the capacity of HB-19 and related Nucant pseudopeptides to block the functioning of surface nucleolin without affecting nuclear nucleolin, which controls many aspects of cellular metabolism [ 1, 3, 15, 37, 38].
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In addition, functionalized nanoparticles themselves or their metabolites can also block the function of ABC transporters such as P-gp by direct or indirect interaction and inhibition.
Stimulated secreted Noggin protein failed to block the function of BMP-2 in the presence of 26SCS.
As a countermeasure, numerous phages are known that produce proteins to block the function of class 1 CRISPR-Cas systems.
Monoclonal antibodies are traditionally used to block the function of a specific target in a given disease.
However, preventing the interaction between two proteins using specific peptides might block the function of key mediators in signaling cascades.
Antibodies that simultaneously block the functions of two or more disease-associated targets are now being developed.
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