Sentence examples for block the final cleavage from inspiring English sources

GSIs are compounds that block the final cleavage of the precursor form of NOTCH, thus preventing generation of ICD and inhibiting NOTCH signaling.

γ-secretase executes the final cleavage step required for the activation of Notch.

The final cleavage (S3) is performed by the γ-secretase complex (Presenilin-Nicastrin-APH1-PEN2).

The final cleavage of acetoacetyl-CoA is performed by YquF [ 127, 128].

BVM prevents the final cleavage of precursor protein p25 to p24 and p2.

Inhibitors of Caspase 3, 8, 9, 10 were added to block the cleavage in a final concentration of 10 mM for 6 hr.

We conclude that Zfy2-induced transcriptional changes severely disrupt the second meiotic division but do not block the first cleavage.

The E682K mutation was thus predicted to block the β′-site cleavage.

A specific inhibitor of furin (dec-RVKR-cmk) fully blocked the substrate cleavage by the WT enzyme.

Treatment with more than 4 mM BAPTA dramatically blocked the inexpedient cleavage of SGK495.

As shown in Figure 1h, z-VAD completely inhibited the apoptosis and also blocked the PARP cleavage.