Sentence examples for block the efflux of from inspiring English sources

All the solutions contain verapamil (50 μM/ml) to block the efflux of Hoechst.

Verapamil was used as a control to effectively block the efflux of the Hoechst dye, which reveals that this method of sorting SP cells is effective.

Evidence for an enzymatic bioconversion and the identification of this specific enzyme could give the possibility to block the efflux of isoprene thereby increasing the amount of isoprenoid available for the synthesis of terpenoids.

Because Hoechst 33342 would be expelled from cells via verapamil sensitive ATP-binding cassette (ABC) transporters, a subset of the cells were incubated with 50 µmol/L verapamil for 30 min at 37°C before adding Hoechst 33342 to block the efflux of fluorescent dye from SP cells within the A549 population.

In a recent review by Gottesman et al. [32], the strategies for circumventing P-gp-mediated MDR are eloquently categorized as follows: using P-gp inhibitors to block the efflux of cytotoxic agents; using drugs that are not substrates of P-gp; and exploiting the properties of MDR cells, such as receptor overexpression and collateral drug sensitivity.

The blockage of MDR efflux pumps through nanoparticles will be helpful in both directions; it blocks the efflux of antibiotic outside the bacterial cells and hence increasing the effect of conventional antibiotics, and also, it blocks the efflux of quorum-sensing biomolecules and hence decreasing biofilm-forming capacity of bacterial cells.

A major advance in our understanding of cholesterol transport was the discovery that a defect in ABCA1 blocks the efflux of cholesterol and phospholipids from cells to apoA1 to form circulating HDL [1], [2], [32] [34].

Consistent with the cytotoxicity data, the drug accumulation results (Figure 1A) indicated that vardenafil significantly enhances intracellular paclitaxel accumulation by blocking the efflux of [3H]-paclitaxel in KB-C2 cells that overexpress ABCB1 (Figure 1A and 2B).

One possibility is that 5β-cholanic acid blocks the efflux of doxorubicin by drug transporters (possibly Abcc1), thereby increasing the retention of doxorubicin in cells.

These TKIs can inhibit or reverse MDR by directly blocking the efflux of ABC transporter substrates, and they play a crucial role in overcoming chemotherapy resistance.

VER is a non-specific inhibitor of ABC transporters and is itself a transport substrate of Pgp and BCRP competing with drugs for the transporter, blocking the efflux of the chemotherapeutic agent.