Sentence examples for block the differentiation of from inspiring English sources
Taken together, these data showed that the amplitudes of SOCE were elevated in the differentiated neuronal cells under the differentiation culture conditions, and the SOCE inhibitor might block the differentiation of A2B5+ NPCs causing cell death.
Interestingly, the overexpression of miR-200 fattenuatesnuathe the downregulation of pluripotency factors in ESCs under the culture condition without LIF, suggesting these miRNAs block the differentiation of ESCs.
Mouse embryonic fibroblasts (MEFs) lacking Akt1 (PKBα) display an inability to differentiate into adipocytes [1] [3], and an RNAi-mediated decrease in Akt1 was found to block the differentiation of 3T3-L1 cells [4], a well-established preadipocyte cell line.
An active mutant of FOXO1 that cannot be phosphorylated and inhibited by Akt was found to block the differentiation of preadipocytes, and this correlated with a loss of PPARγ induction [8].
Therefore, deleting BLIMP1 would block the differentiation of B cells into plasma cells.
OPG has been shown to block the differentiation of osteoclasts, the bone-resorbing cell type.
Indeed, TRAIL-induced apoptosis of osteoblasts differentiated from peripheral blood mononuclear cells in vitro and blocked the differentiation of osteoclasts [ 22– 22].
Addition of neutralizing anti-IL-21 to Th0 + IL-21 cultures completely blocked the differentiation of IL-21 producing CD4 T cells (P = 0.0002; Figure 2B D).
This theory is supported by recent knockdown and knockout studies demonstrating that N-myc is essential in neural stem cells and precursors of the cerebellum for medulloblastoma genesis [22], N-myc plays a key role in blocking the differentiation of cells of origin of medulloblastoma [23], and c-myc is required for glioma stem cell function [24].
It has been demonstrated that iron-labeled neural progenitor cells, mesenchymal stem cells, and hematopoietic stem cells retain their regenerative and therapeutic potential in vivo [32], [33], [34], [35], [36], [40], [41], [42], [43]; however, it has been reported that Feridex complexed with poly-L-lysine blocked the differentiation of human MSCs into chondrocytes [44].
