Sentence examples for block the cascade of from inspiring English sources
Therefore, ASE may block the cascade of cytokine release induced by carrageenan-induced sensitization to produce analgesia in inflammatory pain.
If an IL-18 blocker is developed, however, it may be even more beneficial in that it may block the cascade of inflammation at a point further upstream.
Pre-medication may include benzodiazepines, H1- and H2-receptor antagonists to block the cascade of mast cell mediators, and glucocorticoids as anti-inflammatory and mast cell stabilizers.
Statins have the ability to block the cascade of cholesterol formation by acting on HMG-CoA reductase, reducing the synthesis of endogenous cholesterol.
This study shows that intestinal IPC may block the cascade of events that cause apoptosis that can lead to multiorgan failure.
But after onset of disease the target for TNF inhibition is to block the cascade of inflammatory cell recruitment and for optimal effect the inhibitory molecule should be delivered as soon after disease onset as possible.
Classical AEs as well as AIs are inefficient to block the cascades of events emanating from the membrane and from E2 binding to GPER, leading patients to escape anti-hormone treatments and hormone therapy resistance.
The mainstay of therapy is the avoidance of potential triggers of mast cell degranulation and, if unsuccessful, blocking the cascade of mast cell mediators.
Avoiding medication and physical stimuli that trigger histamine release and blocking the cascade of actions of mast cells constitute the mainstay of therapy besides treatment of anaphylaxis.
For it was reported that VEGF is required for inflammatory neovascularization and a crucial endogenous corneal angiogenic factor, VEGF was confirmed as the key target for blocking the cascade of neovascular formation [ 16, 17].
First, it is possible that rilonacept may have been more effective had it been administered earlier relative to flare onset, since the ability of IL-1 inhibition to effect a reduction in pain by blocking the cascade of downstream inflammatory mediators may depend on the timing of treatment.
