After blocking replication of a temperature-sensitive plasmid carrying a PaeR7I restriction-modification system in Escherichia coli cells, the plasmid was found integrated into the chromosome of the surviving cells.
Another new group of drugs to emerge, the 3C protease inhibitors, are designed to block replication of rhinoviruses once they've penetrated your nasal cells.
Thirteen siRNAs targeting conserved regions of the virus could effectively block replication of CA16 in cultured cells.
To identify inhibitor candidates, we have analyzed hit compounds that emerged from a large-scale high-throughput screen for their ability to block replication of members of both the orthomyxovirus and paramyxovirus families.
We suggest that stress induced by accumulation of aberrant translation products following proteasome inhibition leads to the suppression of cap-dependent translation, explaining why proteasome inhibitors block replication of VSV but not poliovirus replication.
Most drugs employed to eradicate neoplastic disease (e.g. alkylators, cross-linking agents, topoisomerase inhibitors and certain antimetabolites) operate by introducing DNA lesions/intermediates that block replication of rapidly dividing cells, such as cancer cells, and activate cell death responses [1].
This agent, which is in phase 2 clinical trials, is delivered to hepatocytes to block replication of hepatitis C viruses [ 71].
These observations are in agreement with the biological effect of SHPR142 and SHPR190 which are able to block replication of HIV-1 in primary lymphocytes or macrophages when added to the culture medium [ 14].
At various points during infection we added a potent DNA gyrase inhibitor (ciprofloxacin) that blocks replication of DNA in a broad spectrum of bacteria, plasmids and phage (Alonso et al., 1981; Constantinou et al., 1986; Fisher et al., 1989).
In laboratory tests, cystatin C, a protease inhibitor found in human blood, blocks replication of the coronaviruses that cause colds, said Dr. Arlene Collins, associate professor of microbiology at the State University of New York at Buffalo.
