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Initially 32 HBsAg-positive, HBeAg negative volunteers were block randomized by the investigators using a table of random numbers to one of 4 groups: A, B, C, D. The randomization was performed after the decisions for enrollment had been made by the participant and communicated to the study field workers and physicians.
Once therapists have consented to participate in the study they will be block randomized by the coordinating site (by OT or PT discipline) into either treatment arm.
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The study was block randomized by site (block size of 4); allocation sequence was not provided to investigators.
Identified employers were block randomized by size within coalition at a 1 1 ratio to one of two conditions between April 2009 and May 2011, when recruitment was terminated to provide sufficient time for two year follow-up.
Subjects were block-randomized by sex and BMI (<31 vs. ≥31 kg/m) to receive liraglutide (n = 35) or matching placebo (n = 33) once per day by subcutaneous injection.
Participants were block randomized into the two study arms.
Patients were randomized by the Department of Surgery, and treatment allocation was performed by block randomization.
We enrolled 89 participants in the study between June 2006 and July 2009 and block randomized participants by BMI group (18.5 24.9 kg/m or 28.0 40.0 kg/m) and sex to the order of experimental diets.
Subjects enrolled by the clinical investigator were randomized by the statistician per antigen dose, by blocks of 12 subjects, 6 (3 males, 3 females) to each adjuvant cohort.
Animals were randomized by the age at which they became available to enter the study.
Randomization lists were prepared by a biostatistician, according to the block randomized method, with blocks of size 2 to 6. Randomization lists were generated by a computerized program.
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