Sentence examples for block progression of the from inspiring English sources

One approach towards overcoming these limitations is to block progression of the viral replication cycle at an earlier stage than normally occurs with MVA infection.

These structures can potentially block progression of the replication fork and cause intra- or inter-molecular template switching of DNA polymerase between the inverted elements [15], [19].

67– 70 Unrepaired lesions (particularly bulky adducts, intercalations, crosslinks, and helix distortions) can block progression of the replication fork.

These and other damaged bases, if not repaired, may have miscoding properties and lead to mutation upon replication or block progression of the replication fork (11 , 25.

DNA adducts that block progression of the replicative polymerases result in ssDNA gaps on both lagging and leading strands, which can be acted on by TLS polymerases or by recombination.

Although endogenous and environmentally induced DNA damage is primarily removed by DNA repair mechanisms (including nucleotide excision repair, base excision repair, mismatch repair, and various forms of strand break repair), some damage may remain, which can block progression of the normal DNA replication machinery.

p21 blocks progression of the cell cycle at G1/S and is involved in G2/M phase arrest (Dulic et al, 1998).

Probably this good clinical response was due to the anti-angiogenetic effect of cyclophosphamide in blocking progression of the disease without any toxicity, together with successful colostomy to improve the general condition of the patient.

This blocks progression of the cellular cycle, as metaphase chromosomes can no longer achieve the correct configuration, ultimately resulting in cell checkpoint activation and/or stalling of the cell cycle.

At a dose of 8.1 mg/kg, NITD609 exhibited a potent (but not total) ability to inhibit transmission from mouse to mosquito and completely blocked progression of the life cycle to subsequent mice with a single dose.

Gemcitabine is a nucleoside analogue that primarily targets cells undergoing DNA synthesis (S-phase) and also blocks progression of cells through the G1/S-phase boundary.