Sentence examples for block of cell progression from inspiring English sources

With regard to genes differentially expressed in the basal compartment, our results indicate that normal myoepithelial differentiation is associated with the block of cell progression at the G1 phase of the cell cycle, as suggested by the down-regulation of CCNE1.

The compounds show a promising inhibitory growth efficacy (IC50 50–100 μM) in SNU449 cell line, as well as block of cell cycle progression and induction of apoptosis, and can be considered as lead compounds for further SAR developments.

The loss of VRK1 results in a block of cell cycle progression in G1/S.

For the Hsp90 client Cdc2, this could be expected, in particular because the mere reduction of Hsp90α expression had been demonstrated to cause an instability of Cdc2 and a block of cell cycle progression in tissue culture cells [55].

Centrosome dysfunction is also linked to a p53/p21-dependent p53/p21-dependentle progression.

Thus, these results indicate that SAMC affected G0/G1 cell cycle checkpoints and caused a block of cell cycle progression.

The unique mitotic ability of ePG2 and the layer affiliation of additional cells were confirmed by in vivo ablation experiments and layer-specific block of cell cycle progression.

Inhibition of proliferation was due to a block of cell cycle progression in the G0/1 phase, supporting the view that CDKL5 can function as an anti-proliferative gene.

Furthermore, the observation that, in contrast to mature cells, committed luminal cells constitutively express high levels of CCNB1 (similar to bipotent cells, Figure 3 ) suggests that attaining luminal differentiation specifically requires the block of cell cycle progression before entering mitosis.

Campa et al. observed that in adult cardiomyocytes Notch activation is associated with the block of cell cycle progression and apoptosis, suggesting that a prolonged and uncontrolled activation of Notch can be fatal for these cells [ 40].

Block of cell cycle progression in all perineurial glia results in three cells along the NER (as seen in the embryo), indicating that any failure in producing additional perineurial glia cannot be compensated for by other glial subtypes.