Sentence examples for block of cell cycle from inspiring English sources
The compounds show a promising inhibitory growth efficacy (IC50 50–100 μM) in SNU449 cell line, as well as block of cell cycle progression and induction of apoptosis, and can be considered as lead compounds for further SAR developments.
Furthermore, the inhibition effect of liposomes on SW480 colon cancer cells was dramatic enhanced due to a block of cell cycle at G0/G1 phase, and CPL had a higher inhibition rate than bufalin liposomes (BFL) because of the anticancer effect of citrus pectin.
The loss of VRK1 results in a block of cell cycle progression in G1/S.
However, BCL11B- ΔC-2 and wild-type BCL11B overexpression caused a significant block of cell cycle at G0/G1 which correlated well with the DNA-damage resistance.
Treatment of LAN-5 with antagomir-17-5p causes not only a block of cell cycle, but also a dramatic apoptosis.
For the Hsp90 client Cdc2, this could be expected, in particular because the mere reduction of Hsp90α expression had been demonstrated to cause an instability of Cdc2 and a block of cell cycle progression in tissue culture cells [55].
OspA interferes with the response of lymphocytes to proliferative stimuli including a blocking of cell cycle phase progression.
HU (Sigma) was prepared as a 1 M stock solution in ddH2O and used for blocking of cell cycle, at a final concentration of 30 mM.
Our results showed that Sall2 enhanced the p16 minigene blocking of cell cycle progression and p16 knockdown with siRNA abolished most of the Sall2 inhibition of cell cycle progression.
By FACS analysis, various events, such as the blocking of cell cycle, activation of apoptotic genes or proteins, and loss of plasma membrane phospholipid asymmetry, can be detected and quantified to determine the apoptosis pathway [ 23].
