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Blind codes along with random seeds and block length will be recorded in duplicate and delivered to Good Clinical Practice GCPP) Centre of West China Hospital and the sponsor for safekeeping.
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However, codeword block lengths will be chosen such that each codeword is sent completely within a single epoch (note that starting and ending times of epochs are known ahead of time), so that no arrival event occurs during a codeword.
Permuted block randomisation with random block lengths will be used to avoid unequal group sizes [ 57].
The zero-run length will be 0-63 as the total number of elements in a block are 64.
The cycle length will be one year.
Therefore, theoretically, increasing both the filter length of the demixing system and the block length will increase the performance.
The block lengths will vary to ensure the centres are blind to patient allocation.
Let S be the symbol length in bytes, thus each layer has k i ·S bytes and the total length of the block will be K · S = ∑ i = 1 L k i · S bytes.
Block randomisation with randomly varying block sizes will be used.
Block randomisation will be dominant over minimisation.
Random block sizes will be used.
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