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A technology capable of editing mosquito populations to block disease transmission could also be used to alter populations of agricultural plants or livestock by actors intent on doing harm.
Despite the fact that GAS primarily colonizes the mucosal epithelium of the pharynx, the main mechanism of action of most vaccine candidates is based on development of systemic antibodies that do not cross-react with host tissues, neglecting the induction of mucosal immunity that could potentially block disease transmission.
The ability of anti-hTNF therapy to block disease suggested that disease pathology is TNF-driven.
Thus, a chemotherapeutic agent that targets glioblastoma mitochondria may block disease progression.
The passage through the mosquito is a major bottleneck for malaria parasite populations and a target of interventions aiming to block disease transmission.
For example, expression of wild-type Mecp2 in astrocytes of otherwise Mecp2-null mice was shown to significantly block disease progression [ 73].
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Finally, we identify phosphorylation of STAT3 as a novel pathway activated by PPARβ/δ and show that inhibition of STAT3 phosphorylation blocks disease development.
More recently, an IL-15-Fcg2a fusion protein was generated that prevented the development of CIA and also blocked disease progression in an established disease model.
Our data suggest inhibiting PELP1-KDM1-mediated histone modifications as a potential therapeutic strategy for blocking disease progression and therapy resistance among breast cancer patients.
Administration of an IL-15 mutant/fusionfusion protein in established murine CIA blocked disease progression and reduced long term articular inflammation and destruction [ 33].
Moreover, development of the disease involves the coordinated functions of both B cells and T cells, because infusion of nondepleting antibody to CD4 blocks disease, and mice devoid of B cells also do not develop disease [ 13].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com