Sentence examples for block differentiation from inspiring English sources

Afterwards the nonlinear block differentiation must be applied to emulate that performed by pickups [27].

Similarly, Losman and colleagues showed that IDH mutant leukemic transformation is specific to the (R -enantiomer of 2-HG, which can independently pR -enantiomerne independence and blofk differentiation.

Identification of therapeutic targets, which are involved in the survival of CML LSCs such as bcl-2; the self-renewal such as sonic Hh, bmi-1, notch, and Wnt; and the block differentiation such as JAK2/STAT5 activation and HOX gene hypermethylation, will contribute to target LSCs effectively using combinations of small molecule inhibitors and demethylating agents.

This may be due to a high dose of IL-7, which has been reported to block differentiation of adult progenitors into T cells [24], [25].

Nanog is an epiblast-specific transcription factor that acts in concert with Oct4 and may block differentiation into primitive endoderm [32].

They induce proliferation and block differentiation in mouse hematopoietic precursors, and cause leukemia in mice [9], [10], [11], [12], [13], [14].

Hence, blocking differentiation constitutes an important step in neoplastic transformation.

Acute myeloid leukemia (AML) is a group of hematopoietic disorders characterized by uncontrolled proliferation and various degrees of blocked differentiation.

HOXA9 is leukemogenic in mice, and it causes proliferation and blocks differentiation in primary mouse hematopoietic cells in vitro [12], [17].

Conversely, knockdown of miR-30e blocked differentiation of adipocytes.

FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis.