Sentence examples for block constitutive from inspiring English sources

Ludwig, A. et al. Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

To directly test this hypothesis, we examined the effects of 2 substances-brefeldin A (BFA) and cycloheximide (CHX -that are prediCHX -thatelectively block constitutive secretion on the releare of IApredictedmmunoreactovity (IAPP-LI) and immunoreactive inselectively from neonatal rat islet cell monolayer cultures.

Because μ2 RNAi resulted in only a minor defect in synaptic vesicle retrieval, yet was sufficient to block constitutive CME, we conclude that AP-2 is not essential for retrieval at hippocampal synapses.

The authors should test the effect of mutations in the genes that block constitutive (ER-Golgi-plasma membrane) and the regulated (Golgi-secretory storage granules-PM) in sperm attraction and attachment to support their proposal.

When regulated release was prevented by use of calcium-free media, glucose-stimulated IAPP-LI release was nearly abolished by blocking constitutive release with 10 microg/ml BFA (mean +/- SD: 8.7 +/- 7.7 vs. 29.3 +/- 14.3 pmol/l; n = 5; P < 0.05), an inhibitor of constitutive vesicle formation.

Additional point mutations (D66A and D66N) blocked constitutive Gs signaling and lowered ligand-induced Gq signaling.

Erlotinib, a small-molecule EGFR inhibitor, has been shown to inhibit EGFRvIII by blocking constitutive EGFRvIII kinase activity and the growth of EGFRvIII transformed cells [ 27, 28].

Stat3 signaling pathway plays a role in the cell growth and survival of human sarcomas cells because our data also showed that blocking constitutive Stat3 signaling in sarcoma cells induces apoptosis and growth inhibition.

These results reveal, therefore, that methylation in the DUSP16 CpG island not only blocks constitutive expression of DUSP16, but also inhibits the normal, physiological transcriptional upregulation of DUSP16, which occurs in response to stress such as that imposed by sorbitol.

It was also found that blocking constitutive AMPAR endocytosis by interfering with NSF binding to GluA2 subunits does not alter LTD or activity-dependent AMPAR endocytosis (Carroll et al., 1999; Lüscher et al., 1999; Ehlers, 2000; Lee et al., 2002).

Treatment with Alk5 inhibitor in HeLa cells blocked constitutive TGF- β signaling as shown by decreased levels of phosphorylated Smad2, in parallel it also decreased Par-4 protein levels.