Sentence examples for block cell division by from inspiring English sources

The targeted gene knockout studies reported here support the conclusion that the development of therapeutics that impair cell division by inhibiting, but not fully blocking, key regulators of the cell cycle machinery (CDC25s) may have fewer deleterious GI side-effects than chemotherapeutic agents that block cell division by inducing DNA damage.

These agents block cell division by inhibiting the mitotic spindle.

It has been postulated that zeylasteral and demethylzeylasteral, triterpenoids which exhibited antimicrobial activity against Gram-positive bacteria, block cell division by inhibiting DNA synthesis and macromolecular synthesis in Bacillus subtilis.

A link between membrane potential and cell division has been reported previously [8] and ionophores such as carbonyl cyanide m-chloro phenyl hydrazine (CCCP) block cell division by dissipating the proton motive force (PMF) [9].

The most important contribution of this and previous work is that p53 can no longer be regarded as a bona fide "senescence inducer" and that its role is mainly to block cell division (by stimulating p21), thus permitting the onset of senescence program under appropriate conditions [ 7].

PTAX blocks cell division by binding and stabilizing microtubules, which comprise the cytoskeleton and the mitotic spindle [81].

In the Z1.ap/Z4.pa cells, the low level of CKI-1 nonetheless blocks cell division by inhibiting the CYE-1/CDK-2 complex, but CYE-1/CDK-2 still represses terminal differentiation.

Taken together these findings demonstrate that directly blocking the cell division through CDC25 loss is less damaging to the intestinal mucosa than is blocking cell division by inducing DNA damage with chemotherapy.

We report that the phenotypes arising in mice globally deleted for the Cdc25s are due to the failure of small intestinal stem and progenitor cells to proliferate and that blocking cell division by inhibiting the cell cycle engine (through Cdc25 loss) versus by inducing DNA damage (via irinotecan) provokes a markedly different response of small intestinal epithelial cells.

Sirolimus, a macrocyclic lactone, inhibits mammalian target of rapamycin (mTOR) thereby blocking cell division by interfering at the transition from G1 to S phase.

Similar to Class III β-tubulin, Survivin also interacts with microtubules of the mitotic spindle to oppose the action of taxane, which blocks cell division by stabilizing microtubules in the G2/M phase [ 10].