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We also demonstrated that Sox3 had similar effect in NSCs as in glioma cells and and block cell cycle exit, whereas its dominant negative version promote cell cycle exit in both NSCs and glioma cells.
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Rao, V. K. et al. G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation.
Postnatal normoxia increases ROS levels and oxidative damage, inducing cell cycle exit and terminal cardiomyocyte differentiation.
WM-8014 and WM-1119 induce cell cycle exit and cellular senescence winduce celling DNA damage.
We postulate that this role is to inhibit cell cycle progression and promote cell cycle exit.
Altogether, these findings are suggestive of reduced proliferation, premature cell cycle exit and induction of differentiation.
Conversely, overexpression of CBF slows cell cycle exit and delays muscle differentiation.
Thus, thyroid hormones regulate muscle development and function by inducing myoblast cell cycle exit [8].
Our findings suggest that Ngn2 regulates amplification and cell cycle exit of DG granule progenitors.
Notch signaling also regulates cell cycle exit in the lens.
The molecular mechanisms of cell cycle exit are poorly understood.
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