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It is known that methylation of specific cytosine residues in or near transcription regulatory motifs can block accessibility of the transcription factor [ 22- 24].
However, ethanol production from lignocellulosic materials faces more challenges than from starch-based feedstocks as a result of the chemical and physical barriers that block accessibility to the sugars (so-called recalcitrance) within the biomass.
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This phenomenon may be associated with the effect of nanocrystalline TiO2 particles on blocking accessibility of Li ions to the trapping sites which has to be de-trapped if the ions are to be released.
The folded aptamer further blocks accessibility to the surface thus resulting in a decrease in current.
This suggests that lignin in the wild-type secondary cell wall blocks accessibility to such pectic polysaccharides, which are traditionally considered as major components of the primary cell wall and middle lamella.
The oily contamination layer is, thus, only suggested to block the accessibility of aqueous plating solution onto the substrate surface, thereby hindering the coating nucleation at the areas of poor cleaning.
Besides, the linker region can prevent steric hindrance that would block the accessibility of the reactive group or of the tags used for purification.
Whether TrAP might alter KYP conformation or block the accessibility of substrates to the active sites upon interaction awaits future structural analysis.
It is generally accepted that the hydroxy acid form of statins are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme that plays a critical role in cholesterol metabolism, where they block substrate accessibility to HMG-CoA reductase, effectively subverting cholesterol levels of HDL [ 19- 21].
Binding of PspA blocks surface accessibility of this bactericidal peptide preventing it from penetrating the bacterial membrane.
One possibility is that the stable binding of Ubr2 to Tex19.1 blocks the accessibility of Tex19.1 by other E3 ligases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com