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After randomization, there was no blinding to group assignment, except for assessment of the outcomes, which was done by sending questionnaires to the participants by post.
The Cochrane Collaboration risk of bias instrument was used to assess bias across five categories: (1) sequence generation, (2) allocation concealment, (3) blinding to group assignment, (4) incomplete outcome data and (5) incomplete outcome reporting [ 60].
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The sequence was concealed until the intervention was assigned, and investigators were blinded to group assignment.
As indicated above, the recruitment nurse will be blinded to group assignment and also act as the blinded outcome assessor.
Patients and investigators were blinded to group assignment.
Third, anesthesiologists in charge of patients were not blinded to group assignment.
All the participants, those administering the treatments and those assessing the outcomes were blinded to group assignment.
The study substances have identical appearance, smell and viscosity so both the patients and examiners were blinded to group assignment.
Laboratory staff was blind to group assignment.
Those assessing the outcomes were blinded to group assignment.
The user was blinded to group assignment by coded slides.
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