The participants thought it valuable to use observational data to generate hypotheses regarding patient baseline characteristics that are likely to predict clinically important changes in PROs in response to anemia treatment and to design adequately powered blinded randomized controlled trials of anemia treatment using PROs as primary rather than secondary end points.
However, for that to happen we need rigorously conducted, blinded, randomized controlled trials.
Although animal studies consistently demonstrated an advantage of antibiotic prophylaxis, the only two blinded randomized controlled trials could not confirm these findings.
Spinal cord stimulation (SCS), the most widespread application of neuromodulation, became established before the era of evidence-based medicine, which privileges the results of blinded, randomized controlled trials (RCTs) over other forms of clinical evidence.
Data from 3 comparative, blinded, randomized controlled trials (RCTs) have demonstrated the superior efficacy of febuxostat 80 mg daily compared with both the commonly prescribed dose of allopurinol (300 mg) [ 17] and placebo [ 21- 23].
A recently published meta-analysis of 212 blinded, randomized controlled trials (n = 43,049), comparing the efficacy and tolerability of 15 antipsychotic drugs in schizophrenia, found that aripiprazole, quetiapine, asenapine and iloperidone did not cause significantly increased PRL concentrations, compared with placebo.
