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Half of the studies were double blinded, randomised controlled trials whereas the remaining studies were open label, one-group pre and post designs.
In previous blinded randomised controlled trials where the glucagon-like peptide 1 analogues lixisenatide or exenatide DPP4 (dipeptidyl peptidase-4) inhibitors were added to insulin treatment, mostly basal, the absolute reduction in HbA1c level was around 5 mmol/mol (0.5%) greater in the treatment group than in the controls.
Although large-scale blinded randomised controlled trials are difficult to conduct, they are important for validating the efficacy of anti-adhesion agents.
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A two arm double blinded randomised controlled trial was used.
The study is an observer blinded randomised controlled trial.
Design Pragmatic, multicentre, two arm, parallel group, assessor blinded randomised controlled trial (UK Heel Fracture Trial).
To demonstrate effectiveness, a blinded randomised controlled trial (RCT) is, in general, the preferred study design.
This is an assessor blinded randomised controlled trial (RCT) which will be conducted at Austin Health in Melbourne, Australia.
To maintain the original study design of a blinded randomised controlled trial, the treatment code was kept secret for one of the authors who analysed the data (MH).
The study is a multi-centred double blinded randomised controlled trial of thyroid hormone supplementation in babies born below 28 weeks' gestation.
Reimbursement decisions require evidence of effectiveness and, in general, a blinded randomised controlled trial (RCT) is the preferred study design to provide it.
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