Pregabalin and identical placebo capsules were prescribed by the investigator using blinded drug numbers issued by IMPALA.
The following items were coded yes, no, unclear or missing: comparability of cases and controls for geographic origin, age, sample type and methods used to detect and genotype HPV; blinded assessment; numbers of individuals reported at each study stage; and genotype prevalences reported for multiple infections.
NeuN staining was used to count in a blinded manner the number of intact neurons/mm in the CA1 layer.
Study medication was dispensed at each study visit following a telephone call to RAMOS to obtain the next blinded treatment pack number for each patient.
For the 154,215 public sector cataract surgeries included in the study (figure 1), surgeries in the same patient were identified through their blinded clinical record number and hospital identifier (corresponding to 115,104 patients).
Patients were randomly assigned, using a computer-generated randomization schedule, from a central location utilizing an interactive voice response system with blinded medication kit number allocation in a 2 1 ratio to identical-appearing tablets of HZT-501 (800 mg ibuprofen and 26.6 mg famotidine) or ibuprofen (800 mg) thrice daily for 24 weeks.
If un-blinding needed to occur, the study coordinator noted the un-blinded patient's identification number, reason for un-blinding, person responsible for un-blinding study staff, and the list of persons now un-blind to the patient's treatment.
A blinded examiner counted the number of blinks per minute at baseline and before the last block of measurement (after the HFS intervention).
Eudract Number: 2010-020081-22 Blinded assessments.
Digital images of 5 high-power fields from each liver sample were obtained in a random and blinded fashion, and the number of PCNA-labeled nuclei was counted.
Digital images of 5 low-power fields from each liver were obtained in a random and blinded fashion, and the number of BrdU-labeled hepatocyte nuclei was counted.
