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However, the outcome measurements included both self report and blinded measures and when both were available, as with days off school, the blinded measures showed a greater effect, suggesting any reporting bias was in the direction of minimising the intervention effect.
As all outcome measures were self-report, it was not possible to obtain blinded measures of symptomatology.
Furthermore, the study was limited because participating mothers could not be blinded, measures of behaviour were self reported, and a quarter (170/667) of the sample was lost to follow-up.
Similar(57)
Hence, studies of GC regimens have focussed on short-acting GCs given at various frequencies, but avoiding administration 4 6 h before bedtime, in an attempt to mimic circadian plasma cortisol levels and improve short-term non-blinded measures of quality of life.
A Dutch study conducted a 2-armed prospective, multicentre RCT with blinded outcome measures [24].
A Danish study conducted a 2-armed prospective RCT with blinded outcome measures [23].
Dose response curves with blinded outcome measures would improve preclinical data.
The Australian multicenter study was conducted by 25 experienced physiotherapists with unblinded treatment and blinded outcome measures [26].
A Spanish physiotherapist conducted a 2-armed prospective crossover RCT with pairwise comparisons and blinded outcome measures [20].
We will test our hypothesis using a blinded, repeated measures design with random cross-over between conditions.
We will use a blinded repeated measures design with random cross-over between lavender oil and placebo oil.
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