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The reasons for this blinded approach are various.
However, a blinded approach of vessels may cause laceration resulting in severe occult local bleeding.
A single or double blinded approach would require control patients to undergo two false bronchoscopy sessions over the course of the study while under local anesthesia.
A fully blinded approach accentuates the scientific merit of the study results and was therefore considered, but was deemed not appropriate for this study.
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The clinicians each used a pressure algometer along with patient feedback to document the sensitivity of each suspected TrP site, however unlike routine clinical practice, the algometry was performed with a double-blinded approach hence the results were only examined post-hoc.
Slides were randomly coded and examined in a double-blinded approach.
A double-blinded approach was used in all the experimental procedures, including cell counting and data analyses.
The trial design followed a prospective, randomized, subject- and rater-blinded approach enrolling 685 patients from clinical providers specializing in Psychiatry, Internal Medicine, Obstetrics & Gynecology, and Family Medicine.
In their multi-site blinded validation approach the combination of training-testing methods and clinical data (stage, age and sex) showed the best results in predicting the overall survival [ 32].
This so-called PRoBE (prospective specimen collection, blinded evaluation retrospectively) approach strengthens biomarker discovery and validation [ 9].
The CAPER method is distinguished by the use of standardized digital photography, computer-assisted measurements, analysis by an independent reviewer and a blinded, central reader approach.
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