Exact(7)
Second, we validated this method by a blind classification of modern mammalian teeth.
We found a robust molecular signature of thyroid tumor etiology – demonstrated by the correct blind classification of 26 of 29 tumors.
Then, the relevance of the 322 genes of the final signature was proved by blind classification of the 29 testing tumors by a two-step PCA method.
Using this signature, a two-step PCA analysis was used for blind classification of the 29 tumors of the testing set.
The blind classification of an independent set of 29 tumors using this signature led to the correct classification of 26/29 tumors regarding tumor etiology, 1 was undetermined, and 2 were misclassified.
We found two distinct gene expression signatures discriminating sFTA and rFTA, and sPTC and rPTC but, due to the small number of tumors, we did not have enough samples to check the validity of these signatures by blind classification of an independent series of tumors (data not shown).
Similar(53)
At the time of the blind classification the tumor histology, but no radiation exposure history, was known.
In 1976, the International Sports Organization for the Disabled ISODdevelopedped a blind classification system.
Cell counts were performed by two different investigators who were blind to the classification of tissues.
Interviewers were blind to the classification of respondents to the K10 and GHQ-12.
Technicians performing PCR analysis were blinded for histological classification of samples.
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