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Understanding the variability of both the API and the excipients, as well as their impact on the blending process are critical elements for blending QbD.
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Along each ray, the sampling, shading, and blending process is very similar to the regular ray casting algorithm [33, 36].
Scheduling and control of multiproduct blending processes is important in many fields of process systems engineering.
Yet routine use of NIR for monitoring, let alone control of blending processes is not common in the industry, despite the improved process understanding and (cost) efficiency that it may offer.
Subsequently, a DEM-simulation-based characterization of the blending process is performed.
The blending process was executed at different rotation velocities and ended at various time points.
Furthermore, the homogeneity of BAI distribution in a ternary system during the blending process was measured by histogram analysis and moving block macropixel relative standard deviation (MBMRSTDEV).
The development of morphology from pellet-sized particles to submicrometre droplets during the polymer blending process is investigated for several polymer blends.
Similarly, polytetrafluoroethylene (PTFE) nanofibers dispersed in a molten poly(lactic acid) (PLA), which were obtained by mechanical blending process, were found to immigrate to PP during annealing procedure at the temperature between Tm's of PLA and PTFE.
The development of morphology from pellet-sized particles to submicrometre droplets during the polymer-blending process is investigated for two pairs of polymer blends.
An industrially relevant continuous flow blending process has been developed that controllably forms in the melt various structured distributions of carbon black particles to impart uniform or directional conductivities to extrusions such as film, sheet, or tubing.
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