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Many experimental as well as clinical trials demonstrated that the supplementation of AT exerts additional anti-inflammatory effects [5, 24, 25, 39 41]; however, in the clinical setting of sepsis therapy, AT is not recommended as high-dose AT was associated with an increased risk of bleeding when administered with heparin [4].
Similar(59)
As they are cleared by the kidneys, the main potential limitation of LMWH is the potential risk of bioaccumulation and bleeding when administered to patients with renal failure (Nagge et al 2002).
Epsilon-aminocaproic acid is a plasmin inhibitor that potentially reduces perioperative bleeding when administered prophylactically to cardiac surgery patients.
Since AT, particularly when administered with heparin, increases the risk of bleeding significantly, the international guidelines for severe sepsis recommend "not to use high-dose AT for severe sepsis" [ 6].
Strong government authority certainly helped, but only when administered with an even hand.
There were no clinically relevant differences in the PK profile of oxytetracycline when administered alone and when administered with carprofen.
Trastuzumab has been associated with cardiotoxicity, especially when administered with or after doxorubicin.
Pazopanib absorption increases when administered with food, therefore, it is administered in the fasting state.
It is active when administered with either chemotherapy or trastuzumab.
The increased incidence of reinterventions associated with steroids occurred in the absence of increased bleeding events, and thus probably represents an increased severity of bleeding when steroids are administered.
Patients with severe sepsis on renal replacement therapy (RRT), who typically receive additional anticoagulation to prevent circuit clotting, may be at higher risk of bleeding when DrotAA is administered in addition to standard anticoagulation.
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