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In one study, in which 1457 patients with a history of bleeding were compared with 10,000 control individuals, patients on multiple NSAID regimens were nine times more likely to experience upper gastrointestinal bleeding than were control individuals [ 19].
The characteristics of the patients with clinical evidence of bleeding (excluding those with extra-digestive bleeding) were compared with those of the patients without bleeding (Table 3).
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Menstrual experiences of women at risk for a bleeding disorder were compared with those not at risk using chi-square analyses.
This was also the case when HSP patients with severe GI complications (GI bleeding or bowel angina) were compared with those without these complications (Table 3A and B).
The observed bleeding patterns after treatment were compared with usual patterns reported by the participants and with patterns observed in a previous study on women who had not taken any emergency contraceptives.
Previous studies have suggested similar results in populations closely related to AUB. 10, 11 In an analysis by Jensen et al, costs incurred by patients with heavy menstrual bleeding, a type of AUB, were compared with costs of patients without heavy menstrual bleeding.
The bleeding patterns of two variants of a flexible dosing regimen designed to manage intracyclic bleeding problems during extended cycles were compared with that of a conventional OC regimen.
Patients with vitamin K antagonist reversal (reversal group: n = 12) were compared with patients receiving PCC for management of severe bleeding (bleeding group, n = 38).
Meta-analysis showed there was a trend toward decreased overt bleeding when H2RA was compared with sucralfate (OR = 0.87, 95% CI: 0.49 to 1.53).
For policy planners, the nation-wide cost burden of severe bleeding in trauma can be compared with that of other conditions, and potential future costs, such as those resulting from an aging population, can be modelled.
There was no difference in the incidences of renal or electrolyte abnormalities, gastrointestinal bleeding, IVH, and PVL when high dose was compared with the conventional one.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com