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The frequency of wound revision due to bleeding was significantly lower in the thyroid surgery with use of BiClamp compared with conventional ligature (P = 0.022).
As in the RE-COVER trials, major or CRNM bleeding was significantly lower with the use of dabigatran compared with warfarin (HR 0.54; 95 % CI 0.41 0.71).
Major bleeding was significantly lower with apixaban than with dabigatran 150 mg twice daily (by 26%) and rivaroxaban (by 34%), but it was not significantly different from dabigatran 110 mg twice daily.
With regard to patients who were dose-reduced, the rate of major bleeding was significantly lower compared with patients not dose-reduced in the high-dose (p = 0.02 for interaction) and low-dose (p < 0.01 for interaction) edoxaban groups [ 30].
Meta-analyses showed that the incidence of clinically important bleeding was significantly lower in the PPI group as compared with H2RA (OR 0.45, 95% CI (0.21, 0.9), P = 0.04).
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The odds of receiving a transfusion or returning to theatre for bleeding were significantly lower in patients receiving tranexamic acid.
At 30 days, the composite end point of neurologic death, nonfatal stroke, and major bleeding, including intracranial hemorrhage, was significantly lower among patients treated with EPDs compared with those treated with GPIs (0% vs 5.1%, p = 0.02).
53 Overall major and clinically relevant non-major bleeding was similar between rivaroxaban and warfarin (14.9 v 14.5 events/100 patient years; P=0.44), although rates of intracerebral hemorrhage were significantly lower with rivaroxaban (hazard ratio 0.67; P=0.67).
The mean bleeding mass was significantly lower in the fibrinogen concentrate group than in the cryoprecipitate group after 30 minutes.
6 Similarly, in a recent study 13 there were no significant differences in the side effects between the GnRHa and control groups, except for the vaginal bleeding which was significantly lower in the GnRHa group.
Third, bleeding during the ECMO period was significantly lower in the B-group, with a significantly lower need for fresh frozen plasma and platelet concentrate transfusions.
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