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Despite bleeding being the cause of death in some patients, bleeding was not associated with time to death after adjustments for known risk factors.
Bleeding was not associated with any specific variable in our study (antiplatelet medications, p=0.08).
Presence/absence of a postmenopausal bleeding was not associated with tumor stage (p = 0.2) and age at diagnosis (p = 0.5).
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Despite the substantial overlap with consumption of NADs and group sex, fisting and sex-associated rectal bleeding were not associated with a recent history of bacterial STIs, with a higher number of sex partners, or unprotected anal intercourse.
Although bleeding overall was not associated with delay in presentation, the type of bleeding did appear to be important: 35% of patients with rectal bleeding, 30% of patients with vaginal bleeding, but only 9% of patients with urinary bleeding delayed presentation.
Cooper et al reported that bleed length was not associated with PCBs [ 10], but Yucheng women, with cooking oil exposure to PCBs, reported abnormal bleeding more often than controls [ 12].
In a multivariable survival analysis presence/absence of a postmenopausal bleeding prior to diagnosis was not associated with disease free or overall survival (Table 3).
For the diagnosis of placental abruption, we required evidence of blood clot (retroplacental clots) or bleeding behind the placenta accompanied by at least 2 of the following signs and symptoms: 1) vaginal bleeding in late pregnancy that was not associated with placenta previa or cervical lesions; 2) uterine tenderness and/or abdominal pain; and 3) fetal distress or death.
(ii) naso-gastric tube-related lesions (3 vs. 2), (iii) petechial or sub-mucosal bleeding (0 vs. 2), and (iv) duodenal ulcer, (0 vs. 1); the latter was not associated with bleeding but the patient was switched to open label pantoprazole.
Antiplatelet therapy or warfarin prior to ECMO was not associated with bleeding events in univariate analysis, nor was the duration of ECMO.
Prophylactic dalteparin in the preceding 3 days was not associated with bleeding.
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