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Information about the type and pattern of bleeding may help to distinguish secondary from primary bleeding disorders.
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Knowledge of the risk factors for, and frequency of, DVT and bleeding may help clinicians to risk-stratify ICU patients with renal insufficiency, and may help guide appropriate thromboprophylaxis.
This pharmacokinetic analysis completes our previous report on the clinical efficacy and safety of rFVIIa in trauma patients with severe bleeding [ 10] and may help to determine the precise, appropriate dosing regimen in future trials and clinical practice.
It is theoretically possible that the pattern of change in measures of coagulation such as D-dimers may help to identify patients with ongoing bleeding.
Therefore, our pharmacokinetic model may help to target appropriate rFVIIa concentrations in future randomized trials in other clinical conditions, such as postoperative bleeding [ 24, 25].
Even the peashooters can cause collateral damage: aspirin may help to protect against colon cancer, heart attack, and stroke, but it also raises the risk of gastrointestinal bleeding.
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