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There were no significant differences in bleeding incidence or severity.
Regarding the bleeding incidence, combination therapy is reportedly not associated with a risk of bleeding [10].
Major bleeding incidence was higher among those with DM compared with those without, 3.68 (95% confidence interval [CI] 3.37 to 4.03) versus 2.51 (95% CI 2.34 to 2.69) per 100 person-years, and intracranial bleeding incidence was 0.19 (95% CI 0.13 to 0.28) versus 0.25 (95% CI 0.20 to 0.31) per 100 person-years.
As for the anticoagulant effect, Xu et al. [2] were concerned about the increase of bleeding incidence by activated protein C. Similarly, we were afraid of this problem with heparins.
However, bleeding incidence from recurrent varices did not vary significantly.
Confidence interval for bleeding incidence was calculated for 95% level [ 10].
Similar(21)
Frequency of bleeding incidences increased with time as he became more active.
Bleeding events defined by previously published ICD codes lead to lower bleeding incidences (overall 2.5 (2.3 to 2.7)) and smaller differences between current (3.0 (2.6 to 3.3)) and recent exposure (3.4 (2.7 to 4.3)) (see online supplementary table S2).
Given these circumstances, we evaluated the difference in postextraction bleeding incidences in otherwise healthy controls without WF administration (non-WF group) and in patients under reasonable coagulation control with WF WFF group).
For example, Park et al. [ 18] observed 1.7% (1/59) excessive intraextraction bleeding under continued dual antiplatelet therapy but failed to follow up the patients for subsequent bleeding incidences.
In the double blind ROCKET-AF trial patients on rivaroxaban 20 mg od had reduced rates of stroke and systemic embolism and comparable major bleeding incidences compared to warfarin [ 3].
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