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Eight patients received platelet infusion, either for bleeding in combination with fever, or as a prophylactic treatment because of pronounced thrombocytopenia with platelet counts less than 20 × 10 to 30 × 10/L.
It is not clear from our data whether rectal bleeding is a valuable alarm symptom for the presence of inflammatory bowel disease, which is more likely to present as bleeding in combination with altered bowel habit, diarrhoea, abdominal pain, and other related symptoms.
We included cohort studies that assessed the diagnostic utility of rectal bleeding in combination with other symptoms, signs and diagnostic tests in primary care.
Platelet transfusion was given in the event of platelets <10 × 10 l−1 or persistent bleeding in combination with platelets <20 × 10 l−10
Heightened clinical suspicion in patients with chronic pancreatitis with acute abdominal pain and signs of acute bleeding in combination with appropriate diagnostic modalities is mandatory for early and precise diagnosis.
Previous systematic reviews of symptoms also found that clinical features have limited predictive value in identifying patients with cancer [ 76, 77], although a systematic review of rectal bleeding in combination with other symptoms showed that this had modest diagnostic value [ 78].
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Vorapaxar is a potent inhibitor of PAR1 but was associated with an increased risk of intracranial bleeding when used in combination with standard therapy in a phase III trial (TRA-CER).
It is known that aspirin and NSAIDs increase bleeding risk, when used in combination with OAT [ 29].
62 The role of prasugrel and ticagrelor in the future and their bleeding risk when used in combination with DOACs for prevention of stroke and systemic thromboembolism and coronary events remains to be determined.
Peri-implantitis was defined as a loss of marginal bone ≥2 mm in combination with bleeding and/or suppuration on probing and a peri-implant probing depth ≥5 mm [32].
Mice were subjected either to surgical cannulation (ST) alone or in combination with bleeding to a target MAP of 25 mmHg (ST + HS) and maintained in that state for 0 (baseline control), 1, 2, 3, or 4 h in each case.
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