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No major bleeding events were documented in the UC group during the study period.
Major bleeding events were documented in five (36%) patients from these locations: upper gastrointestinal tract (n = 3), nasopharynx, lung, and cannula insertion site (all in one patient), and multilocular intracerebral hemorrhages (n = 1).
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G3-4 hematoxicitytoccurredoccurred in 48 %: G3-4 neuthrombocytopeniaocytopeniandanemiaemia were documented in 35, 30, and 28%% of patients, respectively; clinically relevant bleeding events were noted in 12%% of patients (Table 3).
Women documented the presence and intensity of bleeding on daily diary cards, from which the frequency and duration of bleeding events were calculated.
The bleeding events were recorded throughout the observation period.
When bleeding events were analysed as ordinal data (no bleed, minor bleed, major bleed)[19], significantly increased rates were seen in the triple therapy group (p<0.01).
Adverse bleeding events were also examined.
Bleeding events were recorded for 28 days.
Five major bleeding events were noted.
Bleeding events were categorized into major and minor events.
Major bleeding events and clinically relevant non-major bleeding events were defined according to accepted guidelines.
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