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Strikingly, more than two-thirds of all bleeding events were associated with maximum aPTT values above 75 s.
Serious bleeding events were associated, unsurprisingly, with higher mortality and longer lengths of stay (Table 3).
To investigate whether the bleeding events were associated with sepsis severity, we conducted a subgroup analysis according to sepsis severity.
Similar(57)
Over a 2-fold increased risk of major bleeding events was associated with eGFR < 30.
All serious bleeding events were assessed as 'procedure-related' (if associated with an invasive procedure) or 'non-procedure-related'. Serious bleeding events were recorded for up to 28 days following the start of study drug administration for all but one study (F1K-MC-EVBC).
The bleeding events were recorded throughout the observation period.
Adverse bleeding events were also examined.
Bleeding events were recorded for 28 days.
Five major bleeding events were noted.
Bleeding events were categorized into major and minor events.
Major bleeding events and clinically relevant non-major bleeding events were defined according to accepted guidelines.
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