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No thromboembolic or bleeding episodes were observed during bortezomib retreatment.
However, in a previous clinical trial of cardiac patients who were taking an anti-inflammatory dose of fish oil, in addition to aspirin and Warfarin therapy, no increase in bleeding episodes were observed [ 46].
Although 30% of patients with severe disease had elevated prothrombin time or partial thromboplastin time, no clinically notable bleeding episodes were observed.
We found some evidence to support this possibility since the majority of variceal bleeding episodes were observed before achieving variceal eradication, and bleeding after eradication was a rare event.
Similar(56)
A ≥50% reduction in the number of bleeding episodes was observed in 12 of 16 prophylaxis subjects vs. 2 of 19 on-demand subjects, which is consistent with the PRO-FEIBA study's definition of a good responder 13.
Most of bleeding episodes were minor.
No neutropenic fever or bleeding episodes were recorded.
All bleeding episodes were treated with 1 or 2 injections of rIX-FP.
No severe hypoglycemia episodes were observed.
Severity of bleeding episodes was not different between the two groups (p = 0.62).
Since bleeding episodes are relatively rare events, unreported episodes could greatly affect the study results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com