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A bleeding episode was defined as according to Gerlinger et al. [ 8] as a period of days with bleeding or spotting preceded and followed by at least 2 bleed-free days.
A fatal bleeding episode was defined as a major bleeding episode directly leading to death.
No thromboembolic or bleeding episodes were observed during bortezomib retreatment.
No neutropenic fever or bleeding episodes were recorded.
Recurrent episodes were defined as any bleeding episode lasting 7 or more days or two or more separate bleeding events within the last 12 months.
The episodes were defined as minor when bleeding signs occurred but no transfusion was needed and as major when transfusion of blood or coagulation factors became necessary.
Severity of bleeding episodes was not different between the two groups (p = 0.62).
Since bleeding episodes are relatively rare events, unreported episodes could greatly affect the study results.
A postoperative hemorrhagic episode was defined as any postoperative acute bleeding that resulted in a decrease in serum hemoglobin below 80g/LL, hemodynamic instability, or reoperation.
This episode was defined by looks.
No bleeding episodes were recorded.
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