Exact(7)
Bleed frequency, as well as age, body mass index, and inhibitor formation are known drivers of joint disease and functional limitation in persons with severe haemophilia [6 8].
Prophylaxis regimens initiated at a young age (≤4 years of age) are shown to reduce bleed frequency and joint deterioration later into adulthood [5], and are therefore considered the benchmark in care for severe haemophilia [2].
Our choice of definition, therefore, encompasses an assumption of high bleed frequency via the identification of synovitis, as well as considering the long-term, irreversible changes to the joint tissue and structure that arise from repeat haemorrhage.
Frequent recurrence of bleeding, however, precludes the reinstatement of a baseline level of motion, strength, and physical appearance; inadequate resolution of trauma arising from such events can in turn exacerbate bleed frequency.
Approaches to minimising the long-term risk of joint damage and deterioration among these patients – beginning at a young age with proactive therapy protocols to minimise bleed frequency and severity – will serve to reduce future burdens on hospital systems and are a justification for continued access to preventative therapy protocols.
A 'target joint' as defined in the CHESS study encompasses any joint with known chronic synovitis; in contrast to previous clinical studies [18], study investigators were given discretion as to how this may be further defined with respect to bleed frequency and period of observation.
Similar(53)
To investigate the hormonal contraceptive practices of female university students aged ⩽25 years, their menstrual bleeding frequency, and interest in contraceptive regimens that reduce menstrual frequency or duration.
The bleeding frequency reported in this meta-analysis for apixaban was similar to that reported for the current study.
The intraoperative outcome parameters included incidence of intraoperative bleeding, frequency of endodiathermy, iatrogenic retinal tears and mean surgical time.
In patients with haemophilia A, factor VIII (FVIII) prophylaxis reduces bleeding frequency and joint damage compared with on-demand therapy.
During treatment-free follow-up (n = 34), the reduction in pelvic pain persisted, while bleeding frequency and intensity returned to normal patterns.
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