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They are unaffected by the presence of water, which had long made blasting difficult for open-pit miners.
This makes application of tools like PSI-BLAST difficult, since it relies on clear conservation patterns.
13 Hypocellular MDS without excess blasts is difficult to differentiate from a diagnosis of aplastic anemia.
His difficult blast out of there left him a 12-footer for bogey, which he rolled around the left lip.
But once they turned to inexpensive Chinese-American laborers, who were willing to work for two-thirds of the price of European crews, they were able to blast through technically difficult passes like Bloomer Cut near Sacramento.
Data on the sidedness of the explosive blast itself are difficult to obtain but might also shed information on the asymmetric brain response.
"Twenty years after the blast, it is very difficult to discover who did it," he noted.
The work was dangerous because the rock at the Horsforth end was difficult to blast, and there was frequent flooding and subsidence.
None of these 16 ESTs produced any relevant BLAST hit, making it difficult to predict whether or not they contain coding sequences.
In particular, sequence families exhibiting only short conserved blocks interspersed with highly variable regions are difficult for BLAST or BLAT[ 3] because the seeds have to be very short in this case.
If your cold water (uploading) is on full blast, it'll be difficult to feel much warm water (downloading).
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