Exact(16)
To date, there are four types of coding proteins of R genes against rice blast: (1) NBS-LRR protein; (2) CC-NBS-LRR protein; (3) B-lectin binding and intracellular serine threonine kinase domain protein; and (4) proline-rich protein (Chen et al. 2006; Zhou et al. 2006; Ashikawa et al. 2008; Fukuoka et al. 2009).
Blast 1 was very responsive to staurosporine which indicated that the apoptotic machinery is intact and that the etoposide refractoriness in Blast 1 could be accounted for by failure of DDR to communicate with the apoptotic machinery.
Furthermore, in Blast 1, FLT3L was able to induce both p-Akt and p-S6 signaling in the "low level" basal population.
Notably, in Blast 2 G-CSF mediated greater increases in phosphorylated Stat3 and Stat5 compared to the increases seen in Blast 1.
Analysis of CD33 and CD45 surface expression of all samples within this AML cohort defined three patient samples with two distinguishable leukemic cell subpopulations, referred to as Blast 1 and Blast 2. In all cases, Blast 1 was defined as a cell subset with higher CD33 and CD45 levels, whereas Blast 2 cells had lower levels of these surface proteins.
The two blast populations in sample UHN_8093 were both refractory to etoposide possibly through different mechanisms since there was a greater p-Chk2 response in Blast 1 and a much reduced DDR in Blast 2 (Figure 6B).
Similar(43)
The most established and reliable methods for protein function prediction are based on sequence similarity using BLAST [1] and profile methods such as PFAM [2], and PSI-BLAST [1].
Exploiting correlations in both k-space and time domain, such as k- t BLAST [1]. .
Exploiting correlations in k-space, such as parallel imaging [2, 3]; Exploiting temporal correlations, such as fMRI example of UNFOLD [4]; Exploiting correlations in both k-space and time domain, such as k- t BLAST [1].
In average, Hua1228S expressed moderate resistance to leaf blast (3 level) and neck blast incidence (4 level), and resistance to neck blast loss (1 level) (Fig. 4).
They can blast 106 rounds in less than two minutes.
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