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Azadzoi et al. [ 44] found that hyperlipidemia induced chronic ischemia increases transforming growth factor- β1 in the bladder which leads to fibrosis and noncompliance.
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That is why, if BDL is performed, it is followed by a marked dilation of the gall bladder, which may lead to perforation and choleperitoneum [ 25].
"When women are forced into sex through rape, usually men in a group use a lot of energy during the group sex or 'Kajegere' , thus the victims end up with injured bladder which might lead to obstetric fistula".
" Giving birth from villages, as some of the traditional birth attendants can ask a women in labour to "push in a wrong time" so this strains the bladder which might lead to its rupture thus a woman develops a problem of kayisameinhe after giving birth".
Both were easy to forget in the absence of bladder sensation, which led to several "accidents" when abdominal pressure was raised for example, when standing or coughing.
25D3 is locally converted to 1,25D3 in bladder epithelial cells, binds to VDR, which leads to up-regulation of CAMP and synthesis of cathelicidin.
This causes M-cholinergic receptor hypersensitivity to acetylcholine [ 43] and results in detrusor overactivity which leads to a more ischemic state of bladder wall.
Bladder dysfunction occurs in up to 70% of patients and is characterized by detrusor muscle hyperactivity, which leads to nocturia, urgency and increased urinary frequency [ 34, 46].
Which leads to three thoughts.
Which leads to unholy consummation.
Which leads to easy rust.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com