Administration of saccharin did not increase urinary pH, crystalluria or calculus formation, and failed to promote bladder neoplasia after a carcinogenic dose of MNU, though the numbers of proliferative lesions in the bladder were increased.
The amplitude of contraction of eNOS+/+ bladder segments was increased 2.5 fold compared to control (p<0.01, n = 6), whereas the frequency of spontaneous contractions was significantly decreased (1.35 fold, p<0.05) in stretched tissue strips.
The time to reach peak value for the 99mTc MAG3 renal clearance profile was dependent upon the relative rate of accumulation of the tracer in the kidney compared with the rate of clearance to the bladder and was increased in the Ins2+/−AkitaJ mice.
The risk of bladder cancer was increased in one U.S. dry-cleaner cohort (SMR = 2.22; 95% CI, 1.06 4.08; Ruder et al. 2001) but not in the other (SMR = 1.3; 95% CI, 0.7 2.4; Blair et al. 2003) and not in aircraft workers (Boice et al. 1999).
The frequency of Ca2+-oscillations in SMC contained within bladder tissue sheets was increased by XE991.
SAM68 expression was elevated in MIBC tissues compared with adjacent normal bladder urothelium, and was increased at both transcriptional and translational levels in MIBC tissues compared with NMIBC tissues of the same patient.
Our study demonstrated that the risk of developing bladder cancer in transplant populations was increased.
Previous reports demonstrate that annexin V and transthyretin were downregulated and galectin-1 was increased in bladder cancer [ 41- 43].
Among patients with a parental history of prostate cancer, the risk was increased for bladder (2.44) and skin squamous cell cancers (3.34) and for myeloma (3.85).
Within this study, analysis of 188 tumor specimens confirmed that MMP-10 protein expression was increased in human bladder tumors, and, as in cervical cancer study, a correlation between more aggressive bladder cancers and MMP-10 expression was noted (Additional file 2: Figure S1).
