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To our knowledge, this is the first evidence for a 24 h rhythmic change in bladder smooth muscle activity.
21 Administration of duloxetine lead to a dose dependent increase in bladder capacity and enhanced periurethral striated muscle activity.
Small molecules which act as receptor ligands or inhibitors have been used successfully for neurological problems such as bladder control [11] and epilepsy [12], and for controlling smooth muscle activity [13] although work continues on improving the activity and selectivity over the drugs currently in use.
The early animal studies of the actions of duloxetine on the lower urinary tract indicated that as well as leading to enhanced periurethral striated muscle activity, it also caused a dose dependent increase in bladder capacity.
The most common symptoms of urinary bladder dysfunction were pollakiuria and difficulties in initiating micturition and retention of urine (reduced detrusor muscle activity).
And measurement of muscle activity matters.
Botox injected into the bladder muscle causes the bladder to relax, increasing its storage capacity.
The current TNM bladder cancer staging system stratifies bladder muscle invasion into superficial (pT2a) and deep (pT2b).
Spring-like strain gauges measure muscle activity.
The leggings recorded the muscle activity throughout.
The stagnant urine may cause the precipitation of stones in the bladder; the bladder muscle thickens to overcome this obstruction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com