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Our studies suggest that chronic urothelial β-AR stimulation in these patients may induce COX-2 and iNOS leading to the increased progression of inflammatory pain and bladder hyperexcitability associated with this disease.
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Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury.
Axon terminal hyperexcitability associated with epileptogenesis in vitro.
To directly explore degeneracy in the context of neuropathic pain, we tested whether multiple distinct molecular pathologies are sufficient to produce the cellular hyperexcitability associated with neuropathic pain.
The fact that some of the key symptoms associated with ASD (i.e., communication and behavior) are perceived to be improved by reducing cortical hyperexcitability suggests that the cortical hyperexcitability associated with seizures is not a major part of the neuropathology leading to the cognitive features associated with ASD, at least in the subgroup of children with clinical seizures.
Ratté et al. studied how the degeneracy involved in generating action potentials may affect the development of the hyperexcitability associated with neuropathic pain.
Using computer simulations and experiments, we have demonstrated that primary afferent hyperexcitability associated with neuropathic pain arises through a switch in spike initiation dynamics that occurs when neurons cross a tipping point.
Interestingly, although the cortical hyperexcitability associated with ASD has been attributed to an inhibitory deficit [ 5], many of the AEDs thought to target inhibitory gamma-aminobutyric acid mechanisms were not the ones perceived to be most effective in this population.
Overactive bladder can be associated with a hyperexcitability of bladder afferent C-fibres.
People with neurogenic bladder dysfunction associated with inefficient bladder voiding and the use of catheters are at a high risk of suffering from UTIs.
Accurate assessment of bladder dysfunction associated with voiding dysfunctions often necessitates invasive urodynamic (UD) studies.
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