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We validated the performance of our previously reported test for bladder cancer based on urine gene expression patterns using an independent cohort.
These results revealed that molecular profiling clustered bladder cancer based on histopathogenesis and biological criteria.
The three broad categories of bladder cancer based on management goals and prognosis are nonmuscle invasive bladder cancer (NMIBC), muscle invasive bladder cancer (MBC), and metastatic bladder cancer.
Cases were patients aged 20 80 y living in the geographic catchment areas of the participating hospitals, with histologically confirmed primary bladder cancer based on the 1999 system of the WHO and the International Society of Urological Pathology.
The two constructed cancer and noncancer PPINs were compared to obtain the sets of significant proteins for bladder cancer based on the carcinogenesis relevance value (CRV) for each protein and the statistical assessment.
Combined therapies of Dox or AD198 with inhibitors of PI3K/AKT signaling pathway might lead to more effective treatment outcome for patients diagnosed with bladder cancer based on our in vitro experiments.
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Consistent with the external analysis, however, we found elevated risks for childhood exposure and genitourinary cancers, and for its subcategory, bladder and kidney cancers, based on two cases of bladder cancer.
Decision trees have been used in bladder cancer diagnosis based on SELDI spectrum protein profiles [11].
Hierarchical clustering of gene expression levels grouped bladder cancer specimens based on tumour stage and grade.
At present, conventional diagnosis for urinary bladder cancer is based on morphological, histological and pathological features.
The NRC estimated excess lifetime lung and bladder cancer risks based on a lifetime of exposure to arsenic in drinking water.
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