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The measured concentrations of cimicoxib in the bitch milk are higher than the concentrations measured in plasma leading to quite high milk to plasma concentration ratios of 1.7 to 1.9.
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Among the coagulase-positive, potentially pathogenic staphylococci, Staphylococcus pseudintermedius has been frequently isolated from bitches' milk.
Our results confirm that S. pseudintermedius is the most frequently isolated coagulase-positive staphylococcus from bitches' milk.
Among the coagulase-positive potentially pathogenic staphylococci, Staphylococcus pseudintermedius has been frequently isolated from bitches' milk [ 1, 4], while S. aureus has been only occasionally reported [ 3].
Staphylococcus pseudintermedius was the only coagulase-positive staphylococcus isolated from bitches' milk in our study, confirming previous investigations that reported this species as the most frequently isolated [ 1, 4].
The ideal is replacement bitch's milk.
Our investigation provided valuable information regarding the occurrence, persistence and clinical importance of S. pseudintermedius, and also of MRSP strains, in bitches' colostrum and milk.
From the 18 untreated bitches, 34 samples of foremilk were collected at D1 (2 mammary glands of different bitches were empty), 34 of milk at D7 (2 mammary glands of different bitches were empty) and 30 of milk at D15 (3 bitches could not be sampled).
At present, studies evaluating the transfer of NSAIDs into the milk of bitches are not published.
Thus, the main aim of the present study was to provide some information regarding the transfer of cimicoxib into the milk of bitches for the potential use of the drug in post-caesarean pain relief.
From the nine treated bitches, 16 samples of foremilk were collected at D1 (2 mammary glands of different bitches were empty), 17 of milk at D7 (a mammary gland was empty) and 14 of milk at D15 (2 bitches could not be sampled).
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