Sentence examples for bisphosphonates in the development from inspiring English sources

Preferential prostatic accumulation may partly explain the anticancer effects of alendronate on prostatic tumors, and increase the possibilities of exploiting bisphosphonates in the development of therapies against prostate cancer.

The use of bisphosphonates in preventing the development of bone metastasis is currently under investigation, clodronate and oral bisphosphonate both being investigated as adjuvants.

Table 1 summarizes the effects of bisphosphonates on the development and progression of bone metastases in these models.

While the correlation between use of intravenous injection bisphosphonates and the development of BRONJ is by now widely affirmed in the literature and was reported from 2003 by Marx, 4 less clear and predictable is the correlation between BRONJ and orally administered bisphosphonates.

Here we report a role for bisphosphonates in the prevention of OS development in a high risk model, which would be difficult to evaluate using xenograft models of established OS and osteoblastic metastases.

Bisphosphonates should prevent the development of bone metastasis in breast cancer [ 9, 10].

However, in a model of spontaneous OS, our data reveal a role for bisphosphonates in the prevention or delay of OS development.

Using Bayesian meta-analysis based on the effect size of observational studies as the prior, the posterior probability of OR>1.2 in the development of AF amongst bisphosphonate users in the RCTs was 0.484.

However, a bisphosphonate, a potent calcification inhibitor similar to PC, failed to inhibit the development of OA in Hartley guinea pigs, raising questions about the role of crystals in the development of crystal-associated OA [ 28].

Work in the development department.

With the increasing use of bisphosphonates in the elderly population, this effect needs to be delineated.