Your English writing platform
Discover LudwigExact(2)
The BIS approach is based on the use of circuit equivalent models and Hanai mixture theory [ 4] with the expectation that this method would exhibit superior performance than the SFBIA methods, but to date improvements of BIS over SFBIA have been found to be marginal [ 5].
In our results, serum RANKL remained below detectable levels in our patients who received Bis over a long period, hence osteoclast differentiation via the RANK/RANKL system may have been depressed.
Similar(58)
Inhibition of clathrin-mediated endocytosis inhibited LDL internalization, but not HDL uptake suggesting clathrin-independent mechanisms in hepatocytes and SR-BI over-expressing CHO cells [28].
Indeed, SR-BI plays a crucial role in cholesterol homeostasis and reverse cholesterol transport: Hepatic SR-BI over-expression increases clearance of plasma cholesterol in mice [15 17] and reduces atherosclerosis [18,19].
In contrast to these in-vitro studies in SR-BI over-expressing cells, SR-BI knockout mice display unchanged holo-HDL uptake into the liver, whereas selective lipid uptake is considerably diminished [72].
Consistent with the important role of HDL in reverse cholesterol transport – i.e. the transport of macrophage cholesterol to the feces via biliary excretion – hepatic SR-BI over-expression increases macrophage reverse cholesterol transport [69].
Studies in our lab have focused on extensive characterization of HDL endocytosis using different methodologies: Using ultrasensitive fluorescence microcopy in SR-BI over-expressing cells we found that HDL is endocytosed in clusters of approximately 10 particles.
A second proposed advantage of BI over ML is that Bayesian MCMC provides a more reliable method for analyzing data using complex models that incorporate evolutionary heterogeneity among sites, such as those that use mixture models or partition sites into independent classes [3], [10], [12], [14].
A linear mixed-effect model was applied to compare treatment outcomes (HAMD-17, CGI, and BI) over time between the two groups.
Changes in score from baseline on HAMD-17, CGI-S, and BI over time are illustrated in Table 2 and Figure 2.
SR-BII over-expression was more efficient in enhancing HDL uptake, whereas over-expression of SR-BI was more efficient in increasing selective uptake [56].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com