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6) Reliance on the BIS alone is not recommended.
Some studies have documented that Bis alone or in combination therapy reduces RANKL [ 17, 33, 34].
Bis + statin may confer more benefit to the bone metabolism of these patients compared to Bis alone.
Our findings suggest that both bone resorption and bone formation were inhibited by long-term administration of Bis alone, whereas combination therapy with Bis + statin may be associated with a less marked inhibition of bone metabolism.
Compared with subjects administered Bis alone, the subjects receiving combination therapy had a significant increase in BMD at the lumbar spine after the start of treatment, while the BMD of the radius and femoral neck stayed at baseline levels.
In this study we investigated the effects of Bis, alone or in combination with statins, on bone resorption and bone formation based on BMD and various bone markers in patients with RA who had been receiving Bis for more than 4 years.
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The CINS trial is designed to answer the following questions: 1) Are BI and CBT, and/or BI and seal oil, more effective than BI alone (BI and placebo) in increasing return to work, reducing health complaints, or both?
Methods: Blood from patients with severe BI (Glasgow < 8) collected during the BD process or at the same delay for BI alone.
An extended ROC analysis based on the positive predictive function can thus be performed in order to directly compare the improvement of the combination of VTIQ and BI-RADS to BI-RADS alone.
The combination of BI-RADS greyscale and shear wave elastography yielded superior sensitivity to BI-RADS alone (P=0.03) or shear wave alone (P=0.03).
Chromosome prints based on FI-markers were available for 21 of the 27 autosomes, another three were reconstructed from BI and MI-markers (LGs 22, 25, 27) and the remaining three were based on BI-markers alone (LGs 23, 24, 26), with random 1∶1 designation for the unassigned values as described in Supplement S2.
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