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Furthermore, 1-methoxy-2-propanol exposure in the parental generation of rats significantly alter the sex ratio, the fetal loss, and birthweight reduction in two subsequent generations [34].
The findings suggested a birthweight reduction among low-level smoking mothers with the GSTT1 null genotype (−162.9 g, P = 0.041).
We hypothesized those women with the GSTM1– and GSTT1– null genotype who are exposed to cigarette smoke during pregnancy are at elevated risk for newborn birthweight reduction.
This study shows that even light maternal smoking (mean: 4.8 cigarettes/day) has an increased risk for infant birthweight reduction among genetically susceptible woman.
Maternal tobacco smoke exposure at an epigenome-wide level is associated with placental gene expression and DNA differential methylation and smoking-mediated birthweight reduction [ 44].
A clear association and dose response gradient was present for risk of foetal growth restriction [ 5] and birthweight reduction [ 6] and this effect was evident even in cases of a "minimal" consumption of 1 5 cigarettes per day.
Similar(51)
Although we found a significant reduction in birthweight of babies born to teenage mothers compared to adult mothers, when individualised birthweight ratios (IBRs) were used, teenagers having their first baby did not have an increased risk of delivering either SGA and VSGA babies.
A conscientious attempt at gathering data from all socioeconomic groups would allow researchers and policy-makers to work towards prevention of low birthweight as well as reduction of social disparities in child health.
We found a significant reduction in birthweight to be associated with maternal smoking.
AN has been associated with reduction in birthweight in two pregnancy studies undertaken in PNG [ 15, 20].
36 We hypothesise that metformin will reduce mean birth weight by 0.2 kg, corresponding to a reduction in birthweight centile of 0.33 SD.
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