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In comparison with white Europeans, the markedly higher mean levels of fasting insulin, HOMA-IR, HbA1c and HDL-cholesterol in black African-Caribbeans were largely unaffected by birthweight adjustment; the lower mean levels of urate, triacylglycerol and systolic BP were similarly little affected by birthweight adjustment.
In comparisons with white Europeans, the markedly higher mean levels of fasting insulin, HOMA-IR, HbA1c, glucose, C-reactive protein, triacylglycerol and diastolic BP among South Asians were minimally affected by birthweight adjustment (being reduced by between 14% for fasting glucose and 2% for C-reactive protein); the lower HDL-cholesterol levels in South Asians were little affected.
In parallel analyses without height adjustment (ESM Tables 6 and 7 for South Asians and black Africans, respectively), similar results were observed; birthweight adjustment had very little effect on ethnic differences in risk markers.
Birthweight adjustment had similarly little impact on the magnitude of ethnic differences in the South Asian subgroups, including the larger differences in fasting insulin, urate, triacylglycerol and HDL-cholesterol for Bangladeshis.
The effects of birthweight adjustment on ethnic differences in risk markers between black African-Caribbeans (and black Africans and black Caribbeans separately) and white Europeans in height standardised models are shown in Table 4.
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While there were not any statistically significant differences in gestational age between the two groups, Black infants had a smaller mean gestational age-adjusted birth weight (P = 0.04).> -wrap-foot> aBWr: aBW = gestational age-adjusted birthweight; SD = standard deviation.
Offspring birthweight and low birthweight (LBW, <2,500 g) were considered as study outcomes.
ELBW: extremely low birthweight; FLIC Flexible Information Criterionn; HBW: high birthweight; IUGR: intrauterine growth restriction; MLBW: moderately low birthweight; NBW: normal birthweight; NCHS National Center for Health Statisticss; PMLR: parametric mixtures of logistic regressions; VLBW: very low birthweight The authors declare that they have no competing interests.
Birthweight (SECA 384 scales, Birmingham, UK), sex and gestational age at delivery were recorded.
The outcome measures were preterm birth, very preterm birth, birthweight, SGA (< 5th percentile), very SGA (VSGA< 3rd percentile).
We also noted that children with the lowest birthweight SDS were more likely to be obese and to have experienced wheezing disorder conditions (tables 3 and 5).
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